Recombinant SENP2 antibody

Catalog No. ABIN8093499

The Rabbit Monoclonal anti-SENP2 antibody (Clone 24S77) (ABIN8093499) specifically detects SENP2 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant SENP2 antibody (ABIN8093499)

Target: SENP2 (SUMO1/sentrin/SMT3 Specific Peptidase 2 (SENP2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SENP2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 24S77

Product Details anti-SENP2 Antibody

Purpose: SENP2 Antibody / Small ubiquitin-related modifier 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human Small ubiquitin-related modifier 1 protein was used as the immunogen for the SENP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SENP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SENP2 antibody at -20oC.

Target Details for SENP2

Target: SENP2 (SUMO1/sentrin/SMT3 Specific Peptidase 2 (SENP2))

Alternative Name: SENP2

Background: SENP2 antibody recognizes SUMO-specific protease 2 (SENP2), a cysteine protease that plays a central role in regulating protein sumoylation dynamics within the cell. SENP2 belongs to the sentrin-specific protease family and is responsible for both the maturation of SUMO precursors and the removal of SUMO modifications from target proteins. Through these activities, SENP2 controls the balance between sumoylated and de-sumoylated protein states, influencing numerous cellular processes including transcription, cell cycle progression, and stress responses.

SENP2 is primarily localized to the nucleus, where it associates with nuclear pore complexes and chromatin-associated protein assemblies. Its positioning allows SENP2 to regulate sumoylation of transcription factors, chromatin modifiers, and nuclear structural proteins. By reversing SUMO conjugation, SENP2 modulates protein stability, subcellular localization, and protein-protein interactions. A SENP2 antibody supports research into how dynamic SUMO cycling fine-tunes nuclear signaling and gene regulation.

Functionally, SENP2 acts as a regulatory checkpoint within the SUMO pathway. It processes immature SUMO proteins to expose the C-terminal diglycine motif required for conjugation, while also cleaving SUMO from modified substrates. This dual activity enables SENP2 to influence both the availability of SUMO and the duration of SUMO-dependent signaling events. SENP2-mediated desumoylation is particularly important during cellular stress, mitosis, and differentiation, where rapid changes in protein modification status are required for adaptive responses.

SENP2 expression has been observed across multiple tissues, reflecting its involvement in fundamental cellular functions. Alterations in SENP2 expression or activity have been linked to dysregulated transcriptional control and aberrant cell cycle regulation. In disease-related research, SENP2 has been studied in the context of cancer and cardiovascular biology, where changes in SUMO signaling can affect cell proliferation, survival, and stress tolerance. Monitoring SENP2 expression provides insight into how SUMO-dependent pathways contribute to normal physiology and disease-associated signaling changes.

At the molecular level, the SENP2 gene encodes a protein of approximately 65 kDa that contains a conserved catalytic domain required for SUMO protease activity. Proper SENP2 function depends on its precise subcellular localization and interaction with SUMO-modified substrates. Disruption of SENP2-mediated desumoylation can lead to accumulation of SUMO-conjugated proteins and altered regulatory outcomes. A SENP2 antibody enables detection and analysis of SENP2 expression in research applications focused on post-translational modification, nuclear signaling, and SUMO pathway regulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9HC62

Pathways: Chromatin Binding