TFPI2 antibody (AA 100-235)

Catalog No. ABIN8093520

The Mouse Monoclonal anti-TFPI2 antibody (Clone TFPI2-13028) (ABIN8093520) specifically detects TFPI2 in IHC. The antibody is reactive with Human samples.

Quick Overview for TFPI2 antibody (AA 100-235) (ABIN8093520)

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFPI2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TFPI2-13028

Product Details anti-TFPI2 Antibody

Binding Specificity: AA 100-235

Purpose: TFPI2 Antibody / Tissue factor pathway inhibitor 2

Immunogen: A recombinant fragment (around amino acids 100-235) of human TFPI2 protein (exact sequence is proprietary) was used as the immunogen for the Placental Protein 5/TFPI2 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Placental Protein 5/TFPI2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Placental Protein 5/TFPI2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for TFPI2

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Alternative Name: TFPI2

Background: Placental Protein 5 antibody, also known as TFPI2 antibody, recognizes Placental Protein 5, the historical name for Tissue factor pathway inhibitor 2 encoded by the TFPI2 gene. Originally identified in placental tissue, Placental Protein 5 is a secreted Kunitz-type serine protease inhibitor that associates with the extracellular matrix and regulates pericellular proteolysis. The protein contains three tandem Kunitz domains that enable inhibition of multiple serine proteases involved in matrix degradation and tissue remodeling. Placental Protein 5 antibody is widely used in research examining extracellular matrix regulation, trophoblastic biology, and tumor invasion mechanisms.

TFPI2 is synthesized with a signal peptide and secreted into the extracellular environment, where it binds matrix components and modulates local protease activity. Although structurally related to Tissue factor pathway inhibitor 1, Placental Protein 5 primarily functions in extracellular matrix homeostasis rather than directly regulating the tissue factor coagulation cascade. By inhibiting proteases such as plasmin and trypsin-like enzymes, TFPI2 contributes to maintaining tissue integrity and limiting excessive matrix breakdown. Reduced TFPI2 expression has been reported in various malignancies, often associated with promoter hypermethylation and increased invasive potential.

Expression of Placental Protein 5 has been documented in placenta, vascular endothelium, and selected epithelial tissues. In placental tissue, extracellular and pericellular localization patterns are consistent with its matrix-associated inhibitory role. In cancer biology studies, TFPI2 antibody is frequently used to evaluate epigenetic silencing, stromal interactions, and tumor microenvironment remodeling. Clone TFPI2/13028 is designed to detect Placental Protein 5 in research applications and supports investigation of extracellular protease regulation and matrix-associated signaling pathways.

UniProt: P48307