Kallikrein 6 antibody (KLK6) (AA 200-240)

Details for Product anti-KLK6 Antibody No. ABIN759101
Antigen
  • Bssp
  • Klk7
  • PRSS18
  • PRSS9
  • SP59
  • hK6
  • Prss9
  • AI849898
  • BSP
  • Klk29
  • MSP
  • Prss18
  • neurosin
  • kallikrein related peptidase 6
  • kallikrein related-peptidase 6
  • kallikrein-6
  • KLK6
  • Klk6
  • LOC100716801
Epitope
AA 200-240
14
11
6
5
5
5
3
3
2
2
2
2
1
1
1
1
Reactivity
Human, Rat (Rattus)
87
28
27
2
1
1
Host
Rabbit
89
13
9
Clonality
Polyclonal
Conjugate
This Kallikrein 6 antibody is un-conjugated
12
9
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
80
38
33
12
12
11
10
5
5
3
3
1
1
1
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human KLK6
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others Kallikrein 6 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Klk6 (KLK6 Antibody Abstract)
Background

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Subcellular location: Cytoplasm, Nucleus, Secreted, Mitochondrion

Synonyms: hK6, Bssp, Klk7, SP59, PRSS9, PRSS18, Kallikrein-6, Neurosin, Protease M, Serine protease 18, Serine protease 9, Zyme, KLK6

Gene ID 5653
UniProt Q92876
Pathways Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Kallikrein 6 (KLK6) (AA 200-240) antibody (ABIN759101) Formalin-fixed and paraffin embedded human colon carcinoma tissue labeled with Anti K...
Image no. 2 for anti-Kallikrein 6 (KLK6) (AA 200-240) antibody (ABIN759101) Formalin-fixed and paraffin embedded rat lung labeled with Anti KLK6 Polyclonal Antib...
Image no. 3 for anti-Kallikrein 6 (KLK6) (AA 200-240) antibody (ABIN759101) Antigen: 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:160...
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