HERC3 antibody (N-Term)

Catalog No. ABIN8102296

This Rabbit Polyclonal antibody specifically detects HERC3 in WB. It exhibits reactivity toward Human.

Quick Overview for HERC3 antibody (N-Term) (ABIN8102296)

Target: HERC3 (Hect Domain and RLD 3 (HERC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HERC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HERC3 Antibody

Binding Specificity: N-Term

Purpose: HERC3 Antibody - N-terminal region

Sequence: PLAQVAAGGA HSFALSLSGA VFGWGMNNAG QLGLSDEKDR ESPCHVKLLR

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HERC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43160-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HERC3

Target: HERC3 (Hect Domain and RLD 3 (HERC3))

Alternative Name: HERC3

Background:

Background Information: This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.  

Gene Name: HECT and RLD domain containing E3 ubiquitin protein ligase 3

Protein Name: probable E3 ubiquitin-protein ligase HERC3

Molecular Weight: 115 kDa

Gene ID: 8916

NCBI Accession: NP_055421

UniProt: Q15034