HMBS antibody (C-Term)

Catalog No. ABIN8102862

The Rabbit Polyclonal anti-HMBS antibody (ABIN8102862) specifically detects HMBS in WB. The antibody is reactive with Human samples.

Quick Overview for HMBS antibody (C-Term) (ABIN8102862)

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMBS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HMBS Antibody

Binding Specificity: C-Term

Purpose: HMBS Antibody - C-terminal region

Sequence: VPAQHEDGPE DDPQLVGITA RNIPRGPQLA AQNLGISLAN LLLSKGAKNI

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human HEM3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74562-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HMBS

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Alternative Name: HMBS

Background:

Background Information: This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Name: hydroxymethylbilane synthase

Alternative Symbols: UPS, PBGD, PORC, PBG-D

Protein Name: porphobilinogen deaminase

Molecular Weight: 39kDa

Gene ID: 3145

UniProt: P08397