IL1RAPL1 antibody (C-Term)

Catalog No. ABIN8103314

The Rabbit Polyclonal anti-IL1RAPL1 antibody is suitable to detect IL1RAPL1 in samples from Human. It has been validated for WB.

Quick Overview for IL1RAPL1 antibody (C-Term) (ABIN8103314)

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RAPL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL1RAPL1 Antibody

Binding Specificity: C-Term

Purpose: IL1RAPL1 Antibody - C-terminal region

Sequence: YEYDVPPTGT LPLTSIGNQH TYCNIPMTLI NGQRPQTKSS REQNPDEAHT

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IRPL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP73886-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL1RAPL1

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Alternative Name: IL1RAPL1

Background:

Background Information: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.

Gene Name: interleukin 1 receptor accessory protein like 1

Alternative Symbols: IL1R8, MRX10, MRX21, MRX34, OPHN4, IL1RAPL, TIGIRR-2, IL1RAPL-1, IL-1RAPL-1, IL-1-RAPL-1

Protein Name: interleukin-1 receptor accessory protein-like 1

Molecular Weight: 76kDa

Gene ID: 11141

NCBI Accession: XP_005274498

UniProt: Q9NZN1

Pathways: Synaptic Membrane, Growth Factor Binding