LIN28B antibody (C-Term)

Catalog No. ABIN8104468

This Rabbit Polyclonal antibody specifically detects LIN28B in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Sheep, Dog, Guinea Pig and Rabbit.

Quick Overview for LIN28B antibody (C-Term) (ABIN8104468)

Target: LIN28B (Lin-28 Homolog B (LIN28B))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Sheep, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN28B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LIN28B Antibody

Binding Specificity: C-Term

Purpose: LIN28B Antibody - C-terminal region

Sequence: GCTSPPFPQE ARAEISERSG RSPQEASSTK SSIAPEEQSK KGPSVQKRKK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 86%, Rat: 93%, Sheep: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LN28B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50332-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LIN28B

Target: LIN28B (Lin-28 Homolog B (LIN28B))

Alternative Name: LIN28B

Background:

Background Information: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene Name: lin-28 homolog B

Alternative Symbols: CSDD2

Protein Name: protein lin-28 homolog B

Molecular Weight: 27kDa

Gene ID: 389421

NCBI Accession: NP_001004317

UniProt: Q6ZN17