PLA2G6 antibody (Middle Region)

Catalog No. ABIN8108162

The Rabbit Polyclonal anti-PLA2G6 antibody is suitable to detect PLA2G6 in samples from Human. It has been validated for WB.

Quick Overview for PLA2G6 antibody (Middle Region) (ABIN8108162)

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLA2G6 Antibody

Binding Specificity: Middle Region

Purpose: PLA2G6 Antibody - middle region

Sequence: LFDWVAGTST GGILALAILH SKSMAYMRGM YFRMKDEVFR GSRPYESGPL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PLPL9

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75196-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLA2G6

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Alternative Name: PLA2G6

Background:

Background Information: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.

Gene Name: phospholipase A2 group VI

Alternative Symbols: GVI, PLA2, INAD1, NBIA2, iPLA2, NBIA2A, NBIA2B, PARK14, PNPLA9, CaI-PLA2, IPLA2-VIA, iPLA2beta

Protein Name: 85/88 kDa calcium-independent phospholipase A2

Molecular Weight: 88 kDa

Gene ID: 8398

NCBI Accession: NP_003551

UniProt: O60733

Pathways: Positive Regulation of Peptide Hormone Secretion