SALL3 antibody (N-Term)

Catalog No. ABIN8111107

This Rabbit Polyclonal antibody specifically detects SALL3 in WB. It exhibits reactivity toward Human.

Quick Overview for SALL3 antibody (N-Term) (ABIN8111107)

Target: SALL3 (Sal-Like 3 (SALL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SALL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SALL3 Antibody

Binding Specificity: N-Term

Purpose: SALL3 Antibody - N-terminal region

Sequence: MSRRKQAKPQ HLKSDEELLP PDGAPEHAAP GEGAEDADSG PESRSGGEET

Predicted Reactivity: Cow: 79%, Dog: 79%, Human: 100%, Mouse: 100%, Pig: 85%, Rat: 100%, Zebrafish: 93%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SALL3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39971-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SALL3

Target: SALL3 (Sal-Like 3 (SALL3))

Alternative Name: SALL3

Background:

Background Information: This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.

Gene Name: spalt like transcription factor 3

Alternative Symbols: ZNF796

Protein Name: Sal-like protein 3

Molecular Weight: 143 kDa

Gene ID: 27164

NCBI Accession: NP_741996

UniProt: Q9BXA9