Thyroperoxidase antibody (C-Term)

Catalog No. ABIN8114021

The Rabbit Polyclonal anti-Thyroperoxidase antibody is suitable to detect Thyroperoxidase in samples from Human. It has been validated for WB.

Quick Overview for Thyroperoxidase antibody (C-Term) (ABIN8114021)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Thyroperoxidase Antibody

Binding Specificity: C-Term

Purpose: TPO Antibody - C-terminal region

Sequence: VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL

Predicted Reactivity: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPO

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44312-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: TPO

Background:

Background Information: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.

Gene Name: thyroid peroxidase

Alternative Symbols: MSA, TPX, TDH2A

Protein Name: Thyroid peroxidase

Molecular Weight: 83 kDa

Gene ID: 7173

NCBI Accession: NP_000538

UniProt: P07202

Pathways: Thyroid Hormone Synthesis