BEX1 antibody (AA 55-125)

Catalog No. ABIN760871

Product Details anti-BEX1 Antibody

Target: BEX1 (Brain Expressed, X-Linked 1 (BEX1))

Binding Specificity: AA 55-125

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BEX1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HBEX2/Bex1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BEX1

Target: BEX1 (Brain Expressed, X-Linked 1 (BEX1))

Alternative Name: Bex1 (BEX1 Products)

Synonyms: BEX1 antibody, AA407839 antibody, AU018692 antibody, Bex4 antibody, Rex3 antibody, BEX2 antibody, HBEX2 antibody, HGR74-h antibody, brain expressed X-linked 1 antibody, brain expressed X-linked 2 antibody, brain expressed, X-linked 1 antibody, BEX1 antibody, Bex1 antibody, BEX2 antibody

Background:

Synonyms: BEX2, Brain expressed X linked 1, HBEX2, Protein BEX1, BEX1_HUMAN.

Background: The brain-expressed X-linked (Bex) family of proteins is expressed in the central nervous system, with highest levels detected in cerebellum, temporal lobe and pituitary tissues. Bex1 plays an important role in neuronal differentiation in response to nerve growth factor (NGF), as well as in cell cycle progression. Bex1 is a highly ubiquitinated protein and acts as a link between the cell cycle and neurotrophic factor signaling. Bex2 interacts with LMO2, thereby regulating the transcriptional activity of a DNA-binding complex. Bex1 and Bex 2 are widely expressed outside of the central nervous system with high expression in the liver. Bex1 and Bex2 shuttle between the cytoplasm and the nucleus. Though the role of Bex1 is largely unknown, it may function by coordinating internal cellular states with the ability of cells to respond to external signals.

Gene ID: 55859

Pathways: Neurotrophin Signaling Pathway