BBS7 antibody (AA 85-135)

Catalog No. ABIN8119957

The Rabbit Polyclonal anti-BBS7 antibody (ABIN8119957) specifically detects BBS7 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for BBS7 antibody (AA 85-135) (ABIN8119957)

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BBS7 Antibody

Binding Specificity: AA 85-135

Purpose: BBS7 Antibody

Specificity: This antibody detects endogenous levels of BBS7 at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human BBS7 AA range: 85-135

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BBS7

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Alternative Name: BBS7

Background:

Background: This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy, however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Oct 2014],

Gene Name: BBS7 BBS2L1

Protein Name: BBS7

Gene ID: 55212

UniProt: Q8IWZ6

Pathways: Hedgehog Signaling