BCCIP antibody (AA 60-140)

Catalog No. ABIN8120029

The Rabbit Polyclonal anti-BCCIP antibody (ABIN8120029) specifically detects BCCIP in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for BCCIP antibody (AA 60-140) (ABIN8120029)

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCCIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BCCIP Antibody

Binding Specificity: AA 60-140

Purpose: TOK-1 Antibody

Specificity: TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from TOK-1 . at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Alternative Name: TOK-1

Background:

Synonyms: BCCIP, TOK1, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1

Background: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Gene Name: BCCIP

Protein Name: BRCA2 and CDKN1A-interacting protein

Gene ID: 56647

UniProt: Q9P287