Cadherin 4 antibody (AA 150-250)

Catalog No. ABIN8120093

This Mouse Monoclonal antibody specifically detects Cadherin 4 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Cadherin 4 antibody (AA 150-250) (ABIN8120093)

Target: Cadherin 4 (CDH4)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cadherin 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: AB2351

Product Details anti-Cadherin 4 Antibody

Binding Specificity: AA 150-250

Purpose: R-Cadherin mouse mAb

Specificity: This antibody detects endogenous levels of R-Cadherin protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 150 - 250 of the human R - Cadherin protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Cadherin 4

Target: Cadherin 4 (CDH4)

Alternative Name: R-Cadherin

Background:

Synonyms: Cadherin-4, Retinal cadherin, R-CAD, R-cadherin

Background: cadherin 4 (CDH4) Homo sapiens This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Gene Name: CDH4

Protein Name: R-Cadherin

Gene ID: 1002

UniProt: P55283

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size