Cadherin-16 antibody (AA 700-829)

Catalog No. ABIN8120100

The Mouse Monoclonal anti-Cadherin-16 antibody is suitable to detect Cadherin-16 in samples from Human. It has been validated for IHC.

Quick Overview for Cadherin-16 antibody (AA 700-829) (ABIN8120100)

Target: Cadherin-16 (CDH16)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cadherin-16 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1739

Product Details anti-Cadherin-16 Antibody

Binding Specificity: AA 700-829

Purpose: KSP-Cadherin mouse mAb

Specificity: The antibody can specifically recognize human KSP-Cadherin protein, and has no cross reaction with E-cadherin, N-cadherin, P-cadherin.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 700 - 829 of the human KSP - Cadherin protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Cadherin-16

Target: Cadherin-16 (CDH16)

Alternative Name: KSP-Cadherin

Background:

Synonyms: CAD16_HUMAN, Cadherin 16, Cadherin 16 KSP cadherin, Cadherin kidney, Cadherin-16, CDH 16, CDH16, Kidney cadherin, Kidney specific cadherin, Kidney-specific cadherin, Ksp cadherin, Ksp-cadherin, PRO1340, UNQ695

Background: KSP-cadherin, also known as cadherin-16, is a new member of the calcium adhesion molecule family and plays an important role during embryonic development. It was specifically expressed in kidney, only in renal tubular epithelium, basement membrane and collecting duct epithelium, but not in glomerulus, renal interstitial cells and blood vessels. The loss of these adhesion molecules in renal cell tumors may be related to tumor dedifferentiation and lymph node metastasis. KSP-cadherin has a sensitivity of up to 100 % in renal chromophobe cell carcinoma and 95 % in renal eosinophilic adenoma.

Gene Name: CDH16

Protein Name: KSP-Cadherin

Gene ID: 1014

UniProt: O75309