Caspase 10 antibody (Cleaved-Ala416)

Catalog No. ABIN8120226

The Rabbit Polyclonal anti-Caspase 10 antibody is suitable to detect Caspase 10 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Caspase 10 antibody (Cleaved-Ala416) (ABIN8120226)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Caspase 10 Antibody

Binding Specificity: Cleaved-Ala416

Purpose: Caspase 10 (p12, Cleaved-Ala416) Antibody

Specificity: This antibody detects endogenous levels of Human Caspase 10 (p12, Cleaved-Ala416, protein was cleaved amino acid sequence between 415-416)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human Caspase 10 (p12, Cleaved-Ala416)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Alternative Name: Caspase 10

Background:

Synonyms: Caspase-10 (CASP-10, EC 3.4.22.63, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17, Caspase-10 subunit p12]

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],

Gene Name: CASP10 MCH4

Protein Name: Caspase10

Gene ID: 843

UniProt: Q92851

Pathways: Apoptosis, Caspase Cascade in Apoptosis