CD276 antibody (AA 400-500)

Catalog No. ABIN8120338

The Mouse Monoclonal anti-CD276 antibody (Clone AB2427) (ABIN8120338) specifically detects CD276 in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CD276 antibody (AA 400-500) (ABIN8120338)

Target: CD276

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: AB2427

Product Details anti-CD276 Antibody

Binding Specificity: AA 400-500

Purpose: CD276 mouse mAb

Specificity: This antibody detects endogenous levels of CD276 protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 400 - 500 of the human Beta Tubulin protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background:

Synonyms: CD276;B7H3;PSEC0249;CD276 antigen;4Ig-B7-H3;B7 homolog 3;B7-H3;Costimulatory molecule;CD276

Background: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

Gene Name: CD276

Protein Name: CD276

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints