CCL22 antibody (AA 31-80)

Catalog No. ABIN8120493

The Rabbit Polyclonal anti-CCL22 antibody is suitable to detect CCL22 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for CCL22 antibody (AA 31-80) (ABIN8120493)

Target: CCL22 (Chemokine (C-C Motif) Ligand 22 (CCL22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CCL22 Antibody

Binding Specificity: AA 31-80

Purpose: MDC Antibody

Specificity: This antibody detects endogenous levels of Human MDC

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human MDC AA range: 31-80

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CCL22

Target: CCL22 (Chemokine (C-C Motif) Ligand 22 (CCL22))

Alternative Name: MDC

Background:

Synonyms: C-C motif chemokine 22 (CC chemokine STCP-1, MDC(1-69), Macrophage-derived chemokine, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69), MDC(5-69), MDC(7-69)]

Background: function:May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.,online information:CCL22 entry,PTM:The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the eptdermis and dermis.,

Gene Name: CCL22 MDC SCYA22 A-152E5.1

Protein Name: MDC

Gene ID: 6367

UniProt: O00626