CBX1 antibody (pThr51)

Catalog No. ABIN8120538

The Rabbit Polyclonal anti-CBX1 antibody is suitable to detect CBX1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for CBX1 antibody (pThr51) (ABIN8120538)

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CBX1 Antibody

Binding Specificity: pThr51

Purpose: HP1-β (Phospho Thr51) Antibody

Specificity: This antibody detects endogenous levels of HP1-β (Phospho-Thr51) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human HP1-beta (Phospho-Thr51)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CBX1

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Alternative Name: HP1-beta

Background:

Synonyms: Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)

Background: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],

Gene Name: CBX1 CBX

Protein Name: HP1-β (Phospho-Thr51)

Gene ID: 10951

UniProt: P83916