Claudin 7 antibody (AA 100-211)

Catalog No. ABIN8120615

This Mouse Monoclonal antibody specifically detects Claudin 7 in IHC. It exhibits reactivity toward Human.

Quick Overview for Claudin 7 antibody (AA 100-211) (ABIN8120615)

Target: Claudin 7 (CLDN7)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Claudin 7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1434

Product Details anti-Claudin 7 Antibody

Binding Specificity: AA 100-211

Purpose: Claudin 7 mouse mAb

Specificity: The antibody can specifically recognize human Claudin 7 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 100 - 211 of the human Claudin 7 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: Claudin 7

Background:

Synonyms: CEPTR L2, CEPTRL 2, CEPTRL2, Claudin 1, Claudin 7, Claudin 9, Claudin-7, Claudin1, Claudin7, Claudin9, CLD7_HUMAN, CLDN 7, CLDN-7, CLDN7, Clostridium perfringens enterotoxin receptor like 2, CPETR L2, CPETRL 2, CPETRL2, Hs. 84359

Background: Claudin 7 is a 22 kDa membrane protein, belonging to the tight junction protein family. Claudin family proteins play an important role in cell polarity, signal transduction and the pathogenesis of a variety of malignant tumors. It has been reported that compared with non neoplastic mucosal tissues, the expression of claudin 7 in laryngeal squamous cell carcinoma is down-regulated, and the expression level is related to distant metastasis, which can be used as a potential predictor of poor prognosis. Therefore, claudin 7 may be a useful immunohistochemical marker for the diagnosis, metastasis and prognosis of laryngeal cancer.

Gene Name: CLDN7

Protein Name: Claudin 7

Gene ID: 1366

UniProt: O95471

Pathways: Hepatitis C