C1RL antibody (AA 371-420)

Catalog No. ABIN8120711

This Rabbit Polyclonal antibody specifically detects C1RL in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for C1RL antibody (AA 371-420) (ABIN8120711)

Target: C1RL (Complement Component 1, R Subcomponent-Like (C1RL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1RL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1RL Antibody

Binding Specificity: AA 371-420

Purpose: C1RL Antibody

Specificity: C1RL Polyclonal Antibody detects endogenous levels of C1RL

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human C1RL. at AA range: 371-420

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for C1RL

Target: C1RL (Complement Component 1, R Subcomponent-Like (C1RL))

Alternative Name: C1RL

Background:

Synonyms: Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)

Background: caution:Does not associate with the C1 complex. According to PubMed:15385675 doesn't cleave the proform of complement C1s.,function:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.,induction:Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 CUB domain.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).,

Gene Name: C1RL

Protein Name: C1RL

Gene ID: 51279

UniProt: Q9NZP8