C1S antibody (Cleaved-Ile438, Light Chain)

Catalog No. ABIN8120712

The Rabbit Polyclonal anti-C1S antibody is suitable to detect C1S in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for C1S antibody (Cleaved-Ile438, Light Chain) (ABIN8120712)

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1S antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1S Antibody

Binding Specificity: Cleaved-Ile438, Light Chain

Purpose: C1S (light chain, Cleaved-Ile438) Antibody

Specificity: This antibody detects endogenous levels of Human C1S (light chain, Cleaved-Ile438, protein was cleaved amino acid sequence between 437-438 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human C1S (light chain, Cleaved-Ile438)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Alternative Name: C1S

Background:

Synonyms: Complement C1s subcomponent (EC 3.4.21.42, C1 esterase, Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain]

Background: catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580], that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,

Gene Name: C1S

Protein Name: C1S (light chain, Cleaved-Ile438)

Gene ID: 716

UniProt: P09871

Pathways: Complement System