Exportin 2 antibody (AA 1-100)

Catalog No. ABIN8120761

The Mouse Monoclonal anti-Exportin 2 antibody (Clone AB2423) (ABIN8120761) specifically detects Exportin 2 in WB, IF and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Exportin 2 antibody (AA 1-100) (ABIN8120761)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Clone: AB2423

Product Details anti-Exportin 2 Antibody

Binding Specificity: AA 1-100

Purpose: Cellular Apoptosis Susceptibility/CSE1L mouse mAb

Specificity: This antibody detects endogenous levels of CSE1L.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 1 - 100 of the human Cellular Apoptosis Susceptibility/CSE1L protein.

Isotype: IgG

Application Details

Application Notes: WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: Cellular Apoptosis Susceptibility/CSE1L

Background:

Synonyms: CSE1L,CAS,XPO2,Exportin-2,Exp2,Cellular apoptosis susceptibility protein,Chromosome segregation 1-like protein,Importin-alpha re-exporter

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],

Gene Name: CSE1L

Protein Name: Cellular Apoptosis Susceptibility/CSE1L

Gene ID: 1434

UniProt: P55060

Pathways: Protein targeting to Nucleus