COX2 antibody

Catalog No. ABIN8120863

The Rabbit Monoclonal anti-COX2 antibody (Clone AB1663) (ABIN8120863) specifically detects COX2 in WB, IHC, ELISA, IP and IF. The antibody is reactive with Human samples.

Quick Overview for COX2 antibody (ABIN8120863)

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This COX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: AB1663

Product Details anti-COX2 Antibody

Purpose: MTCO2 Rabbit mAb

Specificity: This antibody detects endogenous levels of MTCO2 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for COX2

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Alternative Name: MTCO2

Background:

Synonyms: Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)

Background: cofactor:Copper A. , disease:Defects in MT-CO2 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110], also called mitochondrial complex IV deficiency. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood. , disease:Defects in MT-CO2 are associated with tumor formation. , function:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. , similarity:Belongs to the cytochrome c oxidase subunit 2 family. ,

Gene Name: MT-CO2 COII COXII MTCO2

Protein Name: MTCO2

Gene ID: 4513

UniProt: P00403

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation