Desmocollin 1 antibody (AA 749-799)

Catalog No. ABIN8120970

The Rabbit Polyclonal anti-Desmocollin 1 antibody is suitable to detect Desmocollin 1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for Desmocollin 1 antibody (AA 749-799) (ABIN8120970)

Target: Desmocollin 1 (DSC1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Desmocollin 1 Antibody

Binding Specificity: AA 749-799

Purpose: DSC1 Antibody

Specificity: This antibody detects endogenous levels of DSC1 at Human/Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human DSC1 AA range: 749-799

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Desmocollin 1

Target: Desmocollin 1 (DSC1)

Alternative Name: DSC1

Background:

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015],

Gene Name: DSC1 CDHF1

Protein Name: DSC1

Gene ID: 1823

UniProt: Q08554