ERN1 antibody

Catalog No. ABIN8121178

The Rabbit Polyclonal anti-ERN1 antibody (ABIN8121178) specifically detects ERN1 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ERN1 antibody (ABIN8121178)

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERN1 Antibody

Purpose: IRE1α Antibody

Specificity: IRE1α Antibody detects endogenous levels of IRE1α protein.

Purification: Affinity purification

Immunogen: Purified recombinant fragment of human IRE1alpha (aa282-433) expressed in E. Coli.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ERN1

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Alternative Name: IRE1alpha

Background:

Synonyms: ERN1, IRE1, Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a

Background: The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008],

Gene Name: ERN1

Protein Name: Serine/threonine-protein kinase/endoribonuclease IRE1

Gene ID: 2081

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response