Glutaredoxin 1 antibody (AA 8-58)

Catalog No. ABIN8121705

The Rabbit Polyclonal anti-Glutaredoxin 1 antibody is suitable to detect Glutaredoxin 1 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for Glutaredoxin 1 antibody (AA 8-58) (ABIN8121705)

Target: Glutaredoxin 1 (GRX1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Glutaredoxin 1 Antibody

Binding Specificity: AA 8-58

Purpose: Glutaredoxin-1 Antibody

Specificity: This antibody detects endogenous levels of human Glutaredoxin-1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Glutaredoxin-1 AA range: 8-58

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Glutaredoxin 1

Target: Glutaredoxin 1 (GRX1)

Alternative Name: Glutaredoxin-1

Background:

Synonyms: Glutaredoxin-1 (Thioltransferase-1; TTase-1)

Background: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011],

Gene Name: GLRX GRX

Protein Name: Glutaredoxin-1

Gene ID: 2745

UniProt: P35754

Pathways: Cell RedoxHomeostasis