HUS1 antibody (AA 160-240)

Catalog No. ABIN8122116

The Rabbit Polyclonal anti-HUS1 antibody is suitable to detect HUS1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for HUS1 antibody (AA 160-240) (ABIN8122116)

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HUS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HUS1 Antibody

Binding Specificity: AA 160-240

Purpose: HUS1 Antibody

Specificity: HUS1 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 160-240

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for HUS1

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Alternative Name: HUS1

Background:

Background: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011],

Gene Name: HUS1

Protein Name: Checkpoint protein HUS1 (hHUS1)

Gene ID: 3364

UniProt: O60921