ICOSLG antibody (AA 201-250)

Catalog No. ABIN8122180

The Rabbit Polyclonal anti-ICOSLG antibody (ABIN8122180) specifically detects ICOSLG in IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ICOSLG antibody (AA 201-250) (ABIN8122180)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICOSLG antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-ICOSLG Antibody

Binding Specificity: AA 201-250

Purpose: CD275 Antibody

Specificity: The antibody detects endogenous CD275

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 201-250

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Alternative Name: CD275

Background:

Synonyms: ICOS ligand (B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD antigen CD275)

Background: alternative products:Additional isoforms seem to exist,function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.,induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.,sequence caution:The sequence differs from that shown in position 300 onward for unknown reason.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.,

Gene Name: ICOSLG B7H2 B7RP1 ICOSL KIAA0653

Protein Name: ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)

Gene ID: 23308

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation