INPPL1 antibody (pTyr1135)

Catalog No. ABIN8122201

The Rabbit Polyclonal anti-INPPL1 antibody (ABIN8122201) specifically detects INPPL1 in WB, IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for INPPL1 antibody (pTyr1135) (ABIN8122201)

Target: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INPPL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-INPPL1 Antibody

Binding Specificity: pTyr1135

Purpose: SHIP2 (Phospho Tyr1135) Antibody

Specificity: This antibody detects endogenous levels of Human SHIP2 (phospho-Tyr1135)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human SHIP2 (Tyr1135)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000, IF ICC 1:50-200,ELISA 1:2000-20000,IHC 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for INPPL1

Target: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Alternative Name: SHIP2

Background:

Synonyms: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)

Background: The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009],

Gene Name: INPPL1 SHIP2

Protein Name: SHIP2 (Tyr1135)

Gene ID: 3636

UniProt: O15357

Pathways: Platelet-derived growth Factor Receptor Signaling