ISR-beta antibody (pTyr1345)

Catalog No. ABIN8122222

The Rabbit Polyclonal anti-ISR-beta antibody (ABIN8122222) specifically detects ISR-beta in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ISR-beta antibody (pTyr1345) (ABIN8122222)

Target: ISR-beta (Insulin Receptor beta (ISR-beta))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISR-beta antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ISR-beta Antibody

Binding Specificity: pTyr1345

Purpose: Insulin Receptor β (Phospho Tyr1345) Antibody

Specificity: This antibody detects endogenous levels of Human Insulin Receptor β (phospho-Tyr1345)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human Insulin Receptor beta (Tyr1345)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for ISR-beta

Target: ISR-beta (Insulin Receptor beta (ISR-beta))

Alternative Name: Insulin Receptor beta

Background:

Synonyms: Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha, Insulin receptor subunit beta]

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Gene Name: INSR

Protein Name: Insulin Receptor β (Tyr1345)

Gene ID: 3643

UniProt: P06213