CD51 antibody (Cleaved-Asp891, Light Chain)

Catalog No. ABIN8122252

The Rabbit Polyclonal anti-CD51 antibody (ABIN8122252) specifically detects CD51 in WB, IHC and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for CD51 antibody (Cleaved-Asp891, Light Chain) (ABIN8122252)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD51 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CD51 Antibody

Binding Specificity: Cleaved-Asp891, Light Chain

Purpose: ITGAV (light chain, Cleaved-Asp891) Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse ITGAV (light chain, Cleaved-Asp891, protein was cleaved amino acid sequence between 890-891 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Alternative Name: ITGAV

Background:

Synonyms: Integrin alpha-V (Vitronectin receptor subunit alpha, CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain, Integrin alpha-V light chain]

Background: integrin subunit alpha V(ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

Gene Name: ITGAV MSK8 VNRA

Protein Name: ITGAV (light chain, Cleaved-Asp891)

Gene ID: 3685

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex