IRF4 antibody (AA 350-451)

Catalog No. ABIN8122292

This Mouse Monoclonal antibody specifically detects IRF4 in IHC. It exhibits reactivity toward Human.

Quick Overview for IRF4 antibody (AA 350-451) (ABIN8122292)

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1262

Product Details anti-IRF4 Antibody

Binding Specificity: AA 350-451

Purpose: IRF-4/MUM1 mouse mAb

Specificity: The antibody can specifically recognize human MUM1 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 350 - 451 of the human IRF - 4/MUM1 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Alternative Name: IRF-4/MUM1

Background:

Synonyms: Interferon regulatory factor 4, IRF 4, IRF-4, Irf4, IRF4_HUMAN, LSIRF, Lymphocyte specific interferon regulatory factor, Lymphocyte specific IRF, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, MUM 1, MUM1, NF EM5, NF-EM5, NFEM5, PU. 1 interaction partner, Sfpi1/PU. 1 interaction partner, Transcriptional activator PIP

Background: MUM1, also known as interferon regulatory factor 4, with a molecular weight of 50 kDa, is a nuclear transcription factor necessary for the development and activation of B lymphocytes. It can regulate the proliferation and differentiation of B cells and activate T lymphocytes. It is mainly used for the study of B-cell lymphoma. It is expressed in multiple myeloma, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma. It can be used as a tissue derived immunophenotypic marker of B-cell lymphoma. At the same time, it is also expressed in RS cells in anaplastic large cell lymphoma, peripheral T-cell lymphoma and classical Hodgkin's lymphoma. It is an immunophenotypic marker of malignant lymphoma, only limited to lymphocytes and melanocytes.

Gene Name: IRF4

Protein Name: IRF-4/MUM1

Gene ID: 3662

UniProt: Q15306

Pathways: Chromatin Binding