Cytokeratin 1 antibody (AA 200-300)

Catalog No. ABIN8122426

The Mouse Monoclonal anti-Cytokeratin 1 antibody (Clone AB1520) (ABIN8122426) specifically detects Cytokeratin 1 in IHC. The antibody is reactive with Human samples.

Quick Overview for Cytokeratin 1 antibody (AA 200-300) (ABIN8122426)

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1520

Product Details anti-Cytokeratin 1 Antibody

Binding Specificity: AA 200-300

Purpose: Cytokeratin 1 Mouse mAb (Ready to Use)

Specificity: The antibody can specifically recognize human CK1 protein. In immunohistochemistry on formalin- fixed, paraffin- embedded tissue sections, the antibody specifically labels only skin epidermal cells, whereas squamous or glandular epithelium cells are not labeled.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 200 - 300 of the human Cytokeratin 1 protein.

Isotype: IgG

Application Details

Application Notes: It has been optimized for direct use, requiring no further dilution.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze

Storage: 4 °C

Storage Comment: Store at 4°C. Avoid freeze.

Target Details for Cytokeratin 1

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Alternative Name: Cytokeratin 1

Background:

Synonyms: 67 kDa cytokeRatin, CK-1, CK1, CytokeRatin-1, CytokeRatin1, EHK, EHK1, Epidermolytic hyperkeRatosis 1, EPPK, Hair alpha protein, K1, K2C1_HUMAN, KeRatin, KeRatin type II cytoskeletal 1, KeRatin-1, KeRatin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keRatin Kb1, Type-II keRatin Kb1

Background: Cytokeratin 1 is a 68 kDa protein with the structure of alpha- helical coiled- coil dimers and it is highly expressed in keratinized squamous epithelium. CK1 forms a complete cellular support network system, provides mechanical strength support for cells, and participates in cell differentiation and intracellular information transmission.   Diseases associated with CK1 include Ichthyosis, Epidermolytic Hyperkeratosis and Palmoplantar Keratoderma, Nonepidermolytic.

Gene Name: KRT1

Protein Name: Cytokeratin 1

Gene ID: 3848

UniProt: P04264