KRT20 antibody (AA 300-424)

Catalog No. ABIN8122479

The Mouse Monoclonal anti-KRT20 antibody is suitable to detect KRT20 in samples from Human, Mouse and Rat. It has been validated for IHC.

Quick Overview for KRT20 antibody (AA 300-424) (ABIN8122479)

Target: KRT20 (Keratin 20 (KRT20))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT20 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1245

Product Details anti-KRT20 Antibody

Binding Specificity: AA 300-424

Purpose: Cytokeratin 20 mouse mAb

Specificity: The antibody can specifically recognize human CK20 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 13, 14, 15, 17, 18.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 300 - 424 of the human Cytokeratin 20 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for KRT20

Target: KRT20 (Keratin 20 (KRT20))

Alternative Name: Cytokeratin 20

Background:

Synonyms: CD20, CK 20, CK-20, CK20, CytokeRatin-20, CytokeRatin20, K1C20_HUMAN, K20, KA20, KeRatin 20, keRatin 20, type I, keRatin 21, Rat, homolog of, KeRatin, KeRatin type I cytoskeletal 20, KeRatin-20, KeRatin20, KRT 20, KRT 21, KRT20, KRT21, MGC35423, OTTHUMP00000164518, Protein IT, type I cytoskeletal 20

Background: CK20 is a cytokeratin with a molecular weight of 46 kDa, which is mainly expressed in gastrointestinal epithelium, urethral epithelium and Merkel cells. It is mainly used for the diagnosis of gastrointestinal adenocarcinoma, ovarian mucinous tumor, Merkel cell carcinoma and cholangiopancreatic adenocarcinoma. CK20 was negative in squamous cell carcinoma, lung adenocarcinoma, endometrial adenocarcinoma, breast cancer, small cell lung cancer and ovarian non mucinous tumor. It is often used in combination with CK7 and villin to judge the tissue source of adenocarcinoma.

Gene Name: KRT20

Protein Name: Cytokeratin 20

Gene ID: 54474

UniProt: P35900