KNG1 antibody

Catalog No. ABIN8122565

This Rabbit Polyclonal antibody specifically detects KNG1 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for KNG1 antibody (ABIN8122565)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KNG1 Antibody

Purpose: Kininogen 1 Antibody

Specificity: This antibody detects endogenous levels of human Kininogen 1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Recombinant Protein derived from human Kininogen 1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: Kininogen 1

Background:

Synonyms: Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain, T-kinin (Ile-Ser-Bradykinin), Bradykinin (Kallidin I), Lysyl-bradykinin (Kallidin II), Kininogen-1 light chain, Low molecular weight growth-promoting factor]

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014],

Gene Name: KNG1 BDK KNG

Protein Name: Kininogen 1

Gene ID: 3827

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process