LIN28A antibody (pSer200)

Catalog No. ABIN8122655

This Rabbit Polyclonal antibody specifically detects LIN28A in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LIN28A antibody (pSer200) (ABIN8122655)

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN28A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LIN28A Antibody

Binding Specificity: pSer200

Purpose: LIN28A (Phospho Ser200) Antibody

Specificity: This antibody detects endogenous levels of Human LIN28A (phospho-Ser200)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human LIN28A (Ser200)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LIN28A

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Alternative Name: LIN28A

Background:

Synonyms: Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1)

Background: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015],

Gene Name: LIN28A CSDD1 LIN28 ZCCHC1

Protein Name: LIN28A (Ser200)

Gene ID: 79727

UniProt: Q9H9Z2

Pathways: Stem Cell Maintenance