LRP6 antibody (pSer1490)

Catalog No. ABIN8122680

The Rabbit Polyclonal anti-LRP6 antibody is suitable to detect LRP6 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for LRP6 antibody (pSer1490) (ABIN8122680)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LRP6 Antibody

Binding Specificity: pSer1490

Purpose: LRP6 (Phospho Ser1490) Antibody

Specificity: This antibody detects endogenous levels of Human LRP6 (phospho-Ser1490)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human LRP6 (Ser1490)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP6

Background:

Synonyms: Low-density lipoprotein receptor-related protein 6 (LRP-6)

Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands.The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

Gene Name: LRP6

Protein Name: LRP6 (Ser1490)

Gene ID: 4040

UniProt: O75581

Pathways: WNT Signaling, Tube Formation