MFN2 antibody

Catalog No. ABIN8122981

The Rabbit Monoclonal anti-MFN2 antibody (Clone AB2008) (ABIN8122981) specifically detects MFN2 in WB, IHC, ELISA, IF and IP. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MFN2 antibody (ABIN8122981)

Target: MFN2 (Mitofusin 2 (MFN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MFN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: AB2008

Product Details anti-MFN2 Antibody

Purpose: Mitofusin-2 Rabbit mAb

Specificity: This antibody detects endogenous levels of Mitofusin-2 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotype: IgG

Application Details

Application Notes: WB, 1:2000-1:10000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: Mitofusin-2

Background:

Synonyms: MFN2, CPRP1, KIAA0214, Mitofusin-2, Transmembrane GTPase MFN2

Background: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

Gene Name: MFN2

Protein Name: Mitofusin-2

Gene ID: 9927

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development