MLKL antibody (AA 40-120)

Catalog No. ABIN8123027

This Rabbit Polyclonal antibody specifically detects MLKL in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for MLKL antibody (AA 40-120) (ABIN8123027)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLKL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MLKL Antibody

Binding Specificity: AA 40-120

Purpose: MLKL Antibody

Specificity: MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from MLKL . at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Synonyms: MLKL, Mixed lineage kinase domain-like protein

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Gene Name: MLKL

Protein Name: Mixed lineage kinase domain-like protein

Gene ID: 197259

UniProt: Q8NB16