MPZ antibody (AA 50-130)

Catalog No. ABIN8123104

The Rabbit Polyclonal anti-MPZ antibody (ABIN8123104) specifically detects MPZ in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MPZ antibody (AA 50-130) (ABIN8123104)

Target: MPZ (Myelin Protein Zero (MPZ))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MPZ Antibody

Binding Specificity: AA 50-130

Purpose: MYP0 Antibody

Specificity: MYP0 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: MYP0

Background:

Background: This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015],

Gene Name: MPZ

Protein Name: Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero)

Gene ID: 4359

UniProt: P25189