NPHP1 antibody (AA 510-590)

Catalog No. ABIN8123264

This Rabbit Polyclonal antibody specifically detects NPHP1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for NPHP1 antibody (AA 510-590) (ABIN8123264)

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPHP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NPHP1 Antibody

Binding Specificity: AA 510-590

Purpose: NPHP1 Antibody

Specificity: NPHP1 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 510-590

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NPHP1

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Alternative Name: NPHP1

Background:

Background: This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding diffe

Gene Name: NPHP1 NPH1

Protein Name: Nephrocystin-1 (Juvenile nephronophthisis 1 protein)

Gene ID: 4867

UniProt: O15259