NPRL2 antibody

Catalog No. ABIN8123346

The Rabbit Polyclonal anti-NPRL2 antibody is suitable to detect NPRL2 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for NPRL2 antibody (ABIN8123346)

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPRL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NPRL2 Antibody

Purpose: NPRL2 Antibody

Specificity: NPRL2 Polyclonal Antibody detects endogenous levels of NPRL2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human NPRL2.

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NPRL2

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Alternative Name: NPRL2

Background:

Synonyms: NPRL2, TUSC4, Nitrogen permease regulator 2-like protein, NPR2-like protein, Gene 21 protein, G21 protein, Tumor suppressor candidate 4

Background: function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,

Gene Name: NPRL2

Protein Name: Nitrogen permease regulator 2-like protein

Gene ID: 10641

UniProt: Q8WTW4