NKX2-1 antibody (AA 50-150)

Catalog No. ABIN8123347

The Rabbit Monoclonal anti-NKX2-1 antibody (Clone AB1688) (ABIN8123347) specifically detects NKX2-1 in IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for NKX2-1 antibody (AA 50-150) (ABIN8123347)

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NKX2-1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1688

Product Details anti-NKX2-1 Antibody

Binding Specificity: AA 50-150

Purpose: Thyroid transcription factor-1 (TTF1) Rabbit mAb (Ready to Use)

Specificity: The antibody can specifically recognize human TTF1 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 50 - 150 of the human Thyroid transcription factor - 1 protein.

Isotype: IgG

Application Details

Application Notes: It has been optimized for direct use, requiring no further dilution.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze

Storage: 4 °C

Storage Comment: Store at 4°C. Avoid freeze.

Target Details for NKX2-1

Target: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Alternative Name: Thyroid transcription factor-1

Background:

Synonyms: AV026640,BCH,Benign chorea,BHC,Homeobox protein NK 2 homolog A,Homeobox protein NK-2 homolog A,Homeobox protein Nkx 2. 1,Homeobox protein Nkx-2. 1,Homeobox protein Nkx2. 1,NK 2,NK 2 homolog A,NK2,NK2 homeobox 1,NK2, drosophila, homolog of, A,NK2. 1, Mouse, homolog of,Nkx 2 1,NKX 2. 1,NKX 2A,NKX2 1,Nkx2-1,NKX2. 1,NKX21_HUMAN,NKX2A,T EBP,T/EBP,TEBP,Thyroid nuclear factor 1,Thyroid nuclear factor,Thyroid specific enhancer binding protein,Thyroid transcription factor 1,Tin man,Tinman,TITF 1,TITF1,TTF 1,TTF-1,TTF1

Background: Thyroid transcription factor 1 (TTF- 1) is a nuclear protein with a molecular weight of 38- 40 kDa. It is the basic material for thyroid differentiation and the regulation of thyroglobulin secretion. It can promote the transport of thyroid peroxidase and iodine / sodium. TTF- 1 is mainly distributed in type II alveolar epithelium, respiratory epithelium and Clara cells of thyroid and lung in adult tissues, but it is not expressed in type I alveolar epithelium. It is mainly used for the diagnosis of small cell lung cancer, the differential diagnosis of primary lung adenocarcinoma from metastatic adenocarcinoma, and the differential diagnosis of lung cancer from malignant mesothelioma and paraganglioma of pleura.

Gene Name: NKX2-1

Protein Name: Thyroid transcription factor-1

Gene ID: 7080

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour