PGC antibody (pSer15)

Catalog No. ABIN8123630

This Rabbit Polyclonal antibody specifically detects PGC in WB, IHC and ELISA. It exhibits reactivity toward Plant.

Quick Overview for PGC antibody (pSer15) (ABIN8123630)

Target: PGC (Pepsinogen C (PGC))

Reactivity: Plant

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PGC Antibody

Binding Specificity: pSer15

Purpose: PEPC (Phospho Ser15) Antibody

Specificity: The antibody detects endogenous PEPC (Phospho Ser15) protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic Peptide of PEPC (Phospho Ser15)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, containing 0.5 % BSA, 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: PEPC

Background:

Synonyms: PGC, Gastricsin, Pepsinogen C

Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],

Gene Name: PGC

Protein Name: Gastricsin

Gene ID: 5225

UniProt: P20142