Phospholipase C beta 2 antibody

Catalog No. ABIN8123765

This Rabbit Polyclonal antibody specifically detects Phospholipase C beta 2 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Phospholipase C beta 2 antibody (ABIN8123765)

Target: Phospholipase C beta 2 (PLCb2) (phospholipase C beta 2 (PLCb2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C beta 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Phospholipase C beta 2 Antibody

Purpose: PLC β2 Antibody

Specificity: PLC β2 Polyclonal Antibody detects endogenous levels of PLC β2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human PLC beta2.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Phospholipase C beta 2

Target: Phospholipase C beta 2 (PLCb2) (phospholipase C beta 2 (PLCb2))

Alternative Name: PLC beta2

Background:

Synonyms: PLCB2, 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-2, Phosphoinositide phospholipase C-beta-2, Phospholipase C-beta-2, PLC-beta-2

Background: catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 1 calcium ion per subunit.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with RAC1.,

Gene Name: PLCB2

Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Gene ID: 5330

UniProt: Q00722

Pathways: WNT Signaling, Thyroid Hormone Synthesis, CXCR4-mediated Signaling Events, G-protein mediated Events, Thromboxane A2 Receptor Signaling