PMS2CL/PMS2 antibody (AA 600-700)

Catalog No. ABIN8123821

The Mouse Monoclonal anti-PMS2CL/PMS2 antibody (Clone AB2348) (ABIN8123821) specifically detects PMS2CL/PMS2 in IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for PMS2CL/PMS2 antibody (AA 600-700) (ABIN8123821)

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMS2CL/PMS2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB2348

Product Details anti-PMS2CL/PMS2 Antibody

Binding Specificity: AA 600-700

Purpose: Postmeiotic Segregation Increased 2 (PMS2) mouse mAb

Specificity: The antibody can specifically recognize human PMS2 protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human Postmeiotic Segregation Increased 2 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for PMS2CL/PMS2

Target: PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))

Alternative Name: Postmeiotic Segregation Increased 2

Background:

Synonyms: DNA mismatch repair gene homologue, DNA mismatch repair protein PMS2, H_DJ0042M02. 9, HNPCC4, Mismatch repair endonuclease PMS2, Mismatch repair gene PMSL2, MLH4, PMS 2, PMS1 homolog 2 mismatch repair system, PMS1 protein homolog 2, PMS2, PMS2 postmeiotic segregation increased 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae) , PMS2_HUMAN, PMS2CL, PMSL2, Postmeiotic segregation increased, S. cerevisiae, 2

Background: Human mismatch repair genes play an important role in maintaining the integrity and stability of genetic information and avoiding genetic mutation. PMS2 is a mismatch repair protein with a molecular weight of 96 kDa, located on chromosome 7. It mainly corrects single base mismatch and small fragment mismatch in vivo. PMS2 forms heterodimer with MLH1 protein and coordinates the binding of other proteins after being activated by ATP to repair DNA errors during cell division. At present, it is mostly used for Lynch syndrome screening together with MLH1, MSH2 and MSH6.

Gene Name: PMS2

Protein Name: Postmeiotic Segregation Increased 2

Gene ID: 5395

UniProt: P54278