PHC3 antibody (AA 720-800)

Catalog No. ABIN8123853

The Rabbit Polyclonal anti-PHC3 antibody is suitable to detect PHC3 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for PHC3 antibody (AA 720-800) (ABIN8123853)

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PHC3 Antibody

Binding Specificity: AA 720-800

Purpose: PHC3 Antibody

Specificity: PHC3 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human protein . at AA range: 720-800

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PHC3

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Alternative Name: PHC3

Background:

Background: function:Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FCS-type zinc finger.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2.,

Gene Name: PHC3 EDR3 PH3

Protein Name: Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)

Gene ID: 80012

UniProt: Q8NDX5