PTRF antibody (pTyr156)

Catalog No. ABIN8123877

The Rabbit Polyclonal anti-PTRF antibody is suitable to detect PTRF in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for PTRF antibody (pTyr156) (ABIN8123877)

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTRF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTRF Antibody

Binding Specificity: pTyr156

Purpose: PTRF (Phospho Tyr156) Antibody

Specificity: This antibody detects endogenous levels of PTRF (Phospho-Tyr156) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human PTRF (Phospho-Tyr156)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PTRF

Target: PTRF (Polymerase I and Transcript Release Factor (PTRF))

Alternative Name: PTRF

Background:

Synonyms: Polymerase I and transcript release factor (Cavin-1)

Background: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrop

Gene Name: PTRF FKSG13

Protein Name: PTRF (Phospho-Tyr156)

Gene ID: 284119

UniProt: Q6NZI2