S100A1 antibody (AA 2-92)

Catalog No. ABIN8124502

The Mouse Monoclonal anti-S100A1 antibody (Clone AB1264) (ABIN8124502) specifically detects S100A1 in IHC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for S100A1 antibody (AA 2-92) (ABIN8124502)

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This S100A1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1264

Product Details anti-S100A1 Antibody

Binding Specificity: AA 2-92

Purpose: S100 Mouse mAb (Ready to Use)

Specificity: The antibody can specifically recognize human S100B protein, and has a weak reaction with S100A1, but no cross reaction with S100A4 or S100A6.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 2 - 92 of the human S100 protein.

Isotype: IgG

Application Details

Application Notes: It has been optimized for direct use, requiring no further dilution.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze

Storage: 4 °C

Storage Comment: Store at 4°C. Avoid freeze.

Target Details for S100A1

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Alternative Name: S100

Background:

Synonyms: NEF, Protein S100 B, Protein S100-B, S 100 calcium binding protein beta chain, S 100 protein beta chain, S-100 protein beta chain, S-100 protein subunit beta, S100, S100 calcium binding protein beta (neural) , S100 calcium-binding protein B, S100 protein beta chain, S100B, S100B_HUMAN, S100beta

Background: S100 comprises 19 members of Ca2+ binding proteins with low molecular weight between 9 kDa to 13 kDa. The S100 falmily proteins have been implicated to regulate protein phosphorylation, cell proliferation and differentiation in the Ca2+- dependent way. S100B is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. It is a useful marker for the identification of melanoma and various nervous system tumors.

Gene Name: S100B

Protein Name: S100

Gene ID: 6285

UniProt: P04271

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins